The vascular protective effects of trihoney in hypercholesterolemic atherosclerotic rabbits, a comparative study with atorvastatin

Atherosclerosis is a chronic inflammatory disease of the inner wall large- and medium-sized arteries. The histopathological lesion atherosclerosis atherosclerotic plaque. This study aimed to investigate vascular protective effects trihoney against development progression plaques. Thirty male New Zealand white (NZW) rabbits were grouped into six groups, comprising five per group as follows: normal diet (C), with 0.6 g/kg/day (C + H), 1% cholesterol (HCD), 0.3 (HCD+H1), (HCD+H2) 2 mg/kg/day atorvastatin (HCD+At). Animals sacrificed after 12 weeks treatment. Atherosclerotic plaques quantified, measured examined using Sudan IV, Hematoxylin Eosin (H&E), Verhoeff-van Gieson (VGS) Masson’s trichrome staining techniques. Trihoney resulted in significant (p < 0.05) reduction number lesions, tunica intima thickness, intima/tunica media thickness ratio. preserved orientation medial elastic tissues exhibited plaque stability effect form subendothelial smooth muscle cells (SMCs) recruitment collagen deposition media. could be recommended natural product future adjuvant statins for management